Connective  tissue is widespread in the body.The principle roles of connective tissue are to bind or strengthen organs or other tissues. It also functions inside the body to divide and compartmentalize other tissue structures. Connective tissues are composed of different types of cells, between which are overlaid  substances of variable  consistency. These include protein-based fibers,  whose most  important function is to provide support to body structures. They are all developed from  the same  jelly-like “ground  substance”, made up of salts and water, protein and carbohydrate. Other cells commonly found in connective tissue include disease-fighting macrophages, antibody - secreting plasma cells and mast cells, which produce histamine to stimulate the dilation of blood vessels at inflammation sites. Embedded in this jelly are the various fibers and cells; elastic fibres to provide elasticity; collagen fibers to provide support; white cells and macrophages to fight infection; fat cells used for storage; and finally plasma cells to produce antibodies.
The proportion of the different types of fibers in the “ground substance” gives the connective  tissue its  variable characteristics.

These include  protein-based fibers, whose most important function is to provide support to body structures. There are many forms of connective tissue. The protein fibers (fibres) come in  three forms; collagen, elastin and reticular fibers* - the proportions of which vary depending on the function of the tissue in which they are found. Each,  however, provides support and strength along with flexibility. The molecules   that form the protein fibers and ground substance are secreted  by specialized  connective tissue cells. (*pertaining to the reticulin: A scleroprotein present in the connective fibers of reticular or lymph tissue).

Loose connective tissue includes adipose tissue, which is specialized for fat storage. One type of dense connective tissue, known as dense regular connective  tissue, forms tendons and cartilage. Another, elastic  connective  tissue is specialized for stretching and is found in the lungs, some artery walls and the vocal chords.

The skeleton keeps the  organs, blood  vessels  and  nerves in place and, to a certain extent,  affords some protection. The connective tissue supports and  binds them together. It also supplies the ligaments  and tendons for the joints and muscles, the tethering for the larger organs, the softness for protection and rigidity in the form of cartilage. Loose connective tissue is found through-out  the organism and has a fundamental  role in the nutrition of all tissues because it allows blood vessels to pass through it. Dense connective tissue is   very strong and makes up tendons and ligaments. There are also other  specialized  types of connective tissue with specific properties, such as adipose tissue, cartilaginous  tissue, bone tissue, blood tissue, and lymphoid tissue. Connective tissue is found holding the cells together within organs. The proportion of different  types of fiber in the  “ground substance”  gives connective  tissue its variable characteristics.

Areolar tissue
Areolar tissue is formed throughout the body  in loose sheets around blood vessels, nerves and tendons; as a soft pliable substance it helps to fill the spaces between larger organs. The tissue is made of a mixture of collagen, elastic and reticulin fibres.This can be seen in the liver substance and in the artery wall itself; here the circular muscle is held in place by a protective sheath of loose areolar tissue. Under  the skin and face it contains a large amount of  mobile, elastic fibres, in contrast to  the  palms of the hands and soles of  the feet, which  are  tough  and  contain  more collagen fibres.

Collagen
Collagen is an important structural protein in the body. It is made up of chains of amino acids, with glycine, proline and hydroxyproline being the most  common. Collagen is often organized in long parallel bundles of fibers, forming  connective tissue,  which has a very high tensile strength (for example tendons  and  ligaments). Collagen may also be formed into sheets (such as  mesenteries of the abdominal cavity).

Fat Cells
Fat cells have three functions: Storage; insulation; protection over certain  areas, such as the buttocks, and around various organs, such as the kidneys and heart and in the liver. Some of the areas of the  body consist mainly of fat storage cells. Fat cells develop in infancy and then their total number remains constant for the rest of life.

Cartilage
Cartilage is a special form of connective tissue and supplies the fabric for the formation of  bone. Cartilage is a  tough, semi-transparent, elastic, flexible  connective tissue consisting of cartilage cells (chondrocytes and chondroblasts) scattered through a glycoprotein material and strengthened  by collagen  fibers. The exterior part of cartilage is covered by dense fibrous membrane called the perichondrium. Adult cartilage does not contain blood vessels or nerves but is filled with small holes to allow nutrition  to seep  into  it.  Cartilage has several functions. It covers the surface joints, allowing bones to slide over one another, thus reducing friction and preventing damage; it also  acts as a shock absorber. It  forms part of the structure of the skeleton in the ribs, where it joins them to the breastbone (sternum). Cartilage is found in the tip of the nose, in the external ear, in the walls of the windpipe (trachea) and  the voice box  (larynx) where it provides support and maintains shape.

Cartilage  comes  in  different  forms, depending  on  its  different physical properties.
This page was last updated: September 16, 2007

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