Neurologic abnormalities can occur in persons with Relapsing Polychondritis.
The most common manifestations are cranial nerve palsies. Any of the cranial nerves may be involved, with Cranial Nerves II, III, IV, VI, VII, VIII, and XI being the most commonly reported.
Optic Neuritis, Hemoplegia, Seizures, Encephalopathy and Rhombencephalonitis have been reported as well. Cerebral aneurysums may also occur.
The underlying mechanism is uncertain. Vasculitis, infection or inflammation in the surrounding areas may account for these neurologic abnormalities.
Other Causes of CNS Alteration
Septic meningitis
(fungal, bacterial, mycobacterial)
Aseptic meningitis
unrelated to RP (viral)
Meniere disease
Temporal arteritis
Malignancy
Drug toxicity
Encephalitis or
meningoencephalitis
Other cause of cerebral vasculitis
Other cause of seizure disorder
Leprosy
